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CARD14‐associated papulosquamous eruption (CAPE) in a toddler responding to treatment with acitretin
Author(s) -
Wong Gabriel Hong Zhe,
Chia Shi Yun,
Wei Heming,
Rafi'ee Khadijah,
Koh Mark Jean Aan,
Tan Ene Choo
Publication year - 2021
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14638
Subject(s) - medicine , acitretin , dermatology , pityriasis rubra pilaris , toddler , refractory (planetary science) , psoriasis , psychology , developmental psychology , physics , astrobiology
Abstract CARD14‐associated papulosquamous eruption (CAPE) is a rare autosomal dominant dermatosis that presents classically in early childhood with clinical features of both psoriasis and pityriasis rubra pilaris (PRP). The disease is known to be refractory to topical and systemic therapies classically used for psoriasis, with the majority of reported cases requiring treatment with biologics, such as ustekinumab and secukinumab. We present a toddler with a clinical presentation consistent with CAPE and found to have a novel heterozygous variant of the CARD14 gene. She was refractory to treatment with topical emollients and topical corticosteroids, but responsive to oral acitretin.