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A rare case of childhood mucous membrane pemphigoid involving the oral and genital mucosa
Author(s) -
Rodriguez Baisi Katinna,
Wentworth Ashley,
Chattha Asma J.,
DiCaudo David J.,
Mangold Aaron,
Nelson Steven A.,
Siegfried Elaine,
Wieland Carilyn N.,
Tollefson Megha
Publication year - 2021
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14627
Subject(s) - medicine , dapsone , mucous membrane , dermatology , cicatricial pemphigoid , sex organ , oral mucosa , lichen sclerosus , rare disease , direct fluorescent antibody , disease , pemphigoid , pathology , bullous pemphigoid , immunology , antibody , genetics , biology
Mucous membrane pemphigoid (MMP) is a rare chronic immunobullous disease that involves the mucous membranes and may result in significant scarring and complications if diagnosis is delayed. MMP typically occurs in elderly patients, with very few cases reported in children. Here, we present a 12‐year‐old female patient with childhood‐onset oral and genital MMP, clinically suspected to be lichen sclerosus, but eventually diagnosed as MMP after multiple supportive biopsies and confirmatory direct immunofluorescence. Although treatment was challenging, the combined use of systemic corticosteroids, dapsone, and mycophenolate mofetil was ultimately successful in achieving disease control.