Premium
The link between hidradenitis suppurativa and phylloid hypomelanosis in partial trisomy‐13 mosaicism: New evidences and further genetic/pathogenetic insights
Author(s) -
Forconi Riccardo,
Bigoni Stefania,
Pacetti Lucrezia,
Host Cristina,
Schettini Natale,
Zedde Pierantonia,
Buldrini Barbara,
Ferlini Alessandra,
Bettoli Vincenzo
Publication year - 2021
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14540
Subject(s) - hidradenitis suppurativa , dermatology , medicine , trisomy , pathology , genetics , biology , disease
Partial trisomy‐13 mosaicism (PT13M) is a rare condition. Among its possible associated cutaneous features, phylloid hypomelanosis (PH), characterized by leaf‐like macules reminiscent of floral ornaments in the form of round or oval spots and patches and oblong lesions, is typical. Two cases of PH associated with hidradenitis suppurativa (HS) have been already reported in the literature. We report a third child with PH due to PT13M associated with HS‐like lesions limited to hypomelanotic regions. We hypothesize that follicular occlusion genes may be located in the duplicated part of chromosome 13.