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New‐onset head and neck dermatitis in adolescent patients after dupilumab therapy for atopic dermatitis
Author(s) -
Bax Christina E.,
Khurana Michele C.,
Treat James R.,
CasteloSoccio Leslie,
Rubin Adam I.,
McMahon Patrick J.
Publication year - 2021
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14499
Subject(s) - dupilumab , medicine , atopic dermatitis , dermatology , malassezia , eczema area and severity index , antifungal , head and neck , disease , surgery
Background/Objectives Head and neck dermatitis after dupilumab therapy for atopic dermatitis has been frequently reported in adults and only rarely in adolescents. No cases detailing disease course and treatment response have previously been described in adolescents. Methods/Results This case series presents five adolescent patients who developed new‐onset or worsening head and neck dermatitis after dupilumab therapy for atopic dermatitis. All five patients improved after oral antifungal therapy. Conclusions The clinical features, treatment response, and potential disease pathogenesis in pediatric patients are described. Adolescents with new‐onset head and neck dermatitis after dupilumab therapy may clinically improve with antifungal therapy, suggesting that Malassezia species may be a contributing factor or antifungal therapy may be an effective antiinflammatory agent.