Premium
An infant with localized vasoconstriction following topical propranolol exposure for infantile hemangioma
Author(s) -
Saerens Julie,
Gutermuth Jan,
Janmohamed Sherief R.
Publication year - 2020
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14475
Subject(s) - propranolol , medicine , vasoconstriction , infantile hemangioma , blockade , hemangioma , dermatology , forehead , anesthesia , surgery , receptor
We describe a 3‐month‐old child with an infantile hemangioma on the forehead with a blanched macule provoked by topical treatment with propranolol. This observation demonstrates that topically applied (non‐selective) beta‐blockers may induce blanched macules at the site of application, a side effect due to peripheral vasoconstriction of blood vessels by non‐selective beta‐2 blockade. This side effect was linked due to overuse and was reversible. This case illustrates the importance of providing thorough instructions regarding topical propranolol application.