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Linear porokeratosis with bone abnormalities treated with compounded topical 2% cholesterol/2% lovastatin ointment
Author(s) -
Blue Elliot,
Abbott James,
Bowen Anneli,
Cipriano Sarah D.
Publication year - 2020
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14447
Subject(s) - porokeratosis , medicine , lovastatin , dermatology , resorption , parakeratosis , dyskeratosis , pathogenesis , cholesterol , pathology , hyperkeratosis , endocrinology
We describe a case of linear porokeratosis with associated bone resorption in a 17‐year‐old female with marked improvement after 2% cholesterol/2% lovastatin ointment application. Porokeratosis is a heterogenous group of keratinization disorders characterized by a cornoid lamella, consisting of focal dyskeratotic cells in the granular layer and columns of parakeratosis. The pathogenesis of porokeratosis is not fully elucidated; however, germline mutations have recently been identified in the mevalonate pathway which can lead to a buildup of metabolites that could play a role in dysmaturation. There has only been one prior report of an affected distal digit with underlying bone resorption in association with linear porokeratosis.