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Pediatric patients with orofacial granulomatosis likely to subsequently develop intestinal Crohn's disease: Brief Report
Author(s) -
Chen Kristen L.,
Diiorio Daren A.,
Chiu Yvonne E.,
Sokumbi Olayemi
Publication year - 2020
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14390
Subject(s) - medicine , disease , crohn's disease , inflammatory bowel disease , retrospective cohort study , dermatology , gastroenterology
Orofacial granulomatosis (OFG) is an uncommon chronic granulomatous condition presenting as perioral inflammation in the absence of systemic disease. There is continued debate regarding whether OFG is a distinct clinical disorder or a manifestation of orofacial Crohn's disease. Our retrospective review identified 7 patients diagnosed with OFG between 2000 and 2018 at a tertiary pediatric hospital. Four of the 7 patients subsequently developed Crohn's disease with a median delay of 3.1 years (range 0.4‐6.9 years). This indicates that gastroenterology evaluation with long‐term monitoring for intestinal Crohn's disease is warranted.