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Pediatric trichodysplasia spinulosa: A report of 2 cases and review of the literature
Author(s) -
Rusk Amanda M.,
Crute Meghan M.,
Goebel Jens,
Schecter Marc G.,
Gupta Anita,
Schwentker Ann R.,
Sheth Anita P.,
Lucky Anne W.
Publication year - 2020
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14323
Subject(s) - medicine , dermatology , immunosuppression , immunostaining , pathology , immunohistochemistry
Trichodysplasia spinulosa is a rare disorder caused by the ubiquitous trichodysplasia spinulosa‐associated polyomavirus (TSPyV) and characterized clinically by predominately centrofacial, but often generalized, folliculocentric papules with protuberant keratinaceous spines. Although seroprevalence reaches up to 70% in adult populations, TSPyV causes clinical manifestations in a small percentage of patients who are immunosuppressed. Diagnosis can be made using typical clinical and histologic features, SV40T antibody immunostaining, and PCR of various tissues including the keratinaceous spine, skin, serum, urine, and CSF. Various topical and systemic medications have demonstrated variable success. Decreasing or discontinuing immunosuppression has also been shown to improve or alleviate clinical manifestations.