Use of topical rapamycin in acral pseudolymphomatous angiokeratoma of children (APACHE): A report of two cases and review of the literature | Zendy

Park Seiwon | Zendy; LaraCorrales Irene | Zendy; Pope Elena | Zendy

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Use of topical rapamycin in acral pseudolymphomatous angiokeratoma of children (APACHE): A report of two cases and review of the literature

Author(s) -

Park Seiwon,

LaraCorrales Irene,

Pope Elena

Publication year - 2020

Publication title -

pediatric dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.542

H-Index - 73

eISSN - 1525-1470

pISSN - 0736-8046

DOI - 10.1111/pde.14240

Subject(s) - medicine , angiokeratoma , dermatology , asymptomatic , dorsum , foot (prosody) , girl , surgery , anatomy , psychology , developmental psychology , linguistics , philosophy

Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare, benign disease characterized clinically by multiple, asymptomatic, erythematous papules in the acral regions. We report APACHE in a 12‐year‐old girl with erythematous‐violaceous papules on the lateral dorsum of her foot and toes, and a 3‐year‐old girl with erythematous papules on the plantar aspect of her foot. Topical rapamycin ointment improved the lesions and both patients tolerated the medication well. Topical rapamycin appears to be a potentially efficacious, well‐tolerated, non‐invasive therapy in APACHE, although further studies are needed.

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