Premium
Use of topical rapamycin in acral pseudolymphomatous angiokeratoma of children (APACHE): A report of two cases and review of the literature
Author(s) -
Park Seiwon,
LaraCorrales Irene,
Pope Elena
Publication year - 2020
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14240
Subject(s) - medicine , angiokeratoma , dermatology , asymptomatic , dorsum , foot (prosody) , girl , surgery , anatomy , psychology , developmental psychology , linguistics , philosophy
Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare, benign disease characterized clinically by multiple, asymptomatic, erythematous papules in the acral regions. We report APACHE in a 12‐year‐old girl with erythematous‐violaceous papules on the lateral dorsum of her foot and toes, and a 3‐year‐old girl with erythematous papules on the plantar aspect of her foot. Topical rapamycin ointment improved the lesions and both patients tolerated the medication well. Topical rapamycin appears to be a potentially efficacious, well‐tolerated, non‐invasive therapy in APACHE, although further studies are needed.