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Transepidermal water loss in the orphan forms of ichthyosis
Author(s) -
Erickson Taylor R.,
Murphrey Morgan B.,
AbuZayed Hajar,
Wu Benedict,
Ibler Erin,
Rangel Stephanie M.,
Paller Amy S.
Publication year - 2020
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14221
Subject(s) - transepidermal water loss , ichthyosis , lamellar ichthyosis , medicine , dermatology , ichthyosis vulgaris , pathology , atopic dermatitis , stratum corneum , filaggrin
As a surrogate measure of skin barrier dysfunction, we sought to determine differences in transepidermal water loss (TEWL) among ichthyosis subtypes and correlate TEWL with clinical severity. Subjects with Netherton syndrome had the highest TEWL values (increased water loss), while TEWL values were lowest in subjects with epidermolytic ichthyosis. TEWL correlated with severity only in lamellar ichthyosis and age was inversely correlated with TEWL ( r s = −.213, P = .02). TEWL is an objective measure that complements disease severity in ichthyosis and may be used as an adjuvant to monitor treatment response.