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A case report of severe dermatitis, allergies, and metabolic wasting (SAM syndrome)
Author(s) -
Rodríguez Tejero Andrea,
Tercedor Sánchez Jesús,
Montero Vilchez Trinidad,
López Delgado David,
Arias Santiago Salvador,
Molina Leyva Alejandro
Publication year - 2020
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14129
Subject(s) - medicine , atopic dermatitis , dermatology , eczematous dermatitis , wasting , allergy , differential diagnosis , immunology , pathology
The presence of eczema and elevated IgE in pediatric patients does not always indicate atopic dermatitis. Rare genodermatoses may share this clinical presentation and should be considered in the differential diagnosis for patients with congenital immunodeficiency and severe refractory dermatitis. We describe a case of severe dermatitis, allergies, and metabolic wasting syndrome, due to a novel mutation in DSG1 gene, an additional example of this uncommon genetic disorder of desmosome function.