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A case of neonatal pemphigus vulgaris with co‐existing BP180 autoantibodies
Author(s) -
Fenner Justine,
Min Michelle S.,
Liu Stephanie,
Silverberg Nanette
Publication year - 2019
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14059
Subject(s) - pemphigus vulgaris , medicine , pemphigus , blisters , bullous pemphigoid , desmoglein 3 , dermatology , pemphigoid , antibody , autoantibody , paraneoplastic pemphigus , immunology
A male neonate was born with blisters on the trunk to a 37‐year‐old primigravid woman with a past medical history of recurrent, painful, topical steroid‐responsive oral blisters. The diagnosis of neonatal pemphigus was made after the neonate and mother were found to have elevated desmoglein 3 (Dsg3) antibodies in conjunction with histopathologic features of pemphigus vulgaris. Interestingly, both neonate and mother also had elevated levels of BP180 antibodies, classically seen in bullous pemphigoid. This case is unique in that it portrays neonatal pemphigus, an already rare condition, complicated by the presence of BP180 antibodies.