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Pediatric Kaposi's sarcoma associated with immune reconstitution inflammatory syndrome
Author(s) -
Silva Leandro,
Azurara Laura,
Monteiro Ana Filipe,
Miroux-Catarino Alexandre,
Amaro Cristina,
Viana Isabel
Publication year - 2019
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14056
Subject(s) - immune reconstitution inflammatory syndrome , immune system , medicine , sarcoma , immunology , inflammation , kaposi's sarcoma , antiretroviral therapy , immunopathology , human immunodeficiency virus (hiv) , pathology , viral load , human herpesvirus
Abstract Immune reconstitution inflammatory syndrome (IRIS) represents paradoxical immune‐mediated inflammation in response to an infecting pathogen, occurring after initiation of antiretroviral therapy (ART), concomitantly with immune system recovery. It has also been described in Kaposi's sarcoma (KS). We report a case of a 9‐year‐old Guinean girl, who developed Kaposi's sarcoma, following introduction of ART. KS associated with immune reconstitution inflammatory syndrome is rare, especially in children, but with the increased use of ART is becoming more prevalent.