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Purpuric nail striae as the initial manifestation in multisystem Langerhans cell histiocytosis
Author(s) -
Prayogo Rizky Lendl,
Rahmayunita Githa,
Agustin Triana,
Sirait Sondang P.,
Arisanty Riesye
Publication year - 2019
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14054
Subject(s) - medicine , langerhans cell histiocytosis , nail (fastener) , dermatology , onycholysis , histiocytosis , pathology , nail plate , disease , paronychia , metallurgy , materials science
Nail involvement in Langerhans cell histiocytosis (LCH) is very uncommon. We describe a 9‐month‐old boy with longitudinal purpuric bands, onychodystrophy, and paronychias on his fingernails and toenails, which antedated manifestations of recurrent bilateral spontaneous pneumothorax and elevated transaminases. The diagnosis of nail LCH was then confirmed by immunohistochemistry demonstrating positive S100 and CD1a staining in the epithelium of nail bed tissue. This case report affirms that nail involvement may be the initial manifestation of multisystem LCH and could portend an unfavorable prognosis.