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The association between atopic dermatitis and serum 25‐hydroxyvitamin D in children: Influence of sun exposure, diet, and atopy features—A cross‐sectional study
Author(s) -
Sanmartin Rosalía,
Pardos Carlos,
Doste Divina,
Aguilera Jose,
Alijarde Roberto,
Jesús AgónBanzo Pedro,
GarcíaMalinis Ana Julia,
Puzo José,
HernándezMartín Ángela,
Gilaberte Yolanda
Publication year - 2020
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14049
Subject(s) - medicine , atopy , vitamin d and neurology , atopic dermatitis , cross sectional study , vitamin d deficiency , asthma , body mass index , population , logistic regression , prospective cohort study , population study , immunoglobulin e , allergy , gastroenterology , immunology , antibody , pathology , environmental health
Background Previous studies have linked low serum vitamin D (VD) or 25‐hydroxyvitamin D (25(OH)D) levels with increased severity of atopic dermatitis (AD) in children. Objective To investigate the association between serum VD (25(OH)D) levels and AD and AD severity, considering the influence of diet and sun exposure. Methods We performed a prospective cross‐sectional study of healthy controls and children diagnosed with AD. Participants were recruited between January 2011 and December 2012, and the following parameters were assessed: age, sex, body mass index (BMI), AD severity, Fitzpatrick skin type, asthma and rhinitis history, dietary VD intake, daily potential sun‐induced VD production, sunscreen use, 25(OH)D and IgE serum levels, and results of the ImmunoCAP Phadiatop Infant test. Results The study population consisted of 105 healthy controls and 134 AD patients. Serum 25(OH)D levels were significantly lower in moderate and severe AD than in mild AD, although this association was only significant for patients with light Fitzpatrick skin type (mean(SD) 36.7 (11.9) ng/mL; moderate 28.8 [11.5] ng/mL; and severe 27.6 [12.1] ng/mL, P = .045). Logistic regression analysis revealed a positive association between severe AD and both positive ImmunoCAP Phadiatop test and BMI. Conclusion Our data support an association between VD deficiency and AD severity only in patients with light complexion.