Tufted angioma with associated Kasabach‐Merritt phenomenon caused by somatic mutation in GNA 14

Tufted angioma ( TA ) is a rare vascular tumor characterized by histologic tufts of proliferating capillaries that occurs in infancy or early childhood, with a poorly understood pathogenesis. Though benign, TA can be associated with the Kasabach‐Merritt phenomenon ( KMP ), a life‐threatening consumptive coagulopathy and thrombocytopenia. Here, we explored the genetic mechanism underlying a case of TA associated with KMP via targeted sequencing of laser capture micro‐dissected lesion and blood DNA , and identified a somatic, activating GNA 14 mutation specific to the tumor. Our findings support aberrant GNA 14 activation underlies the pathogenesis of TA associated with KMP .