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Topical tacrolimus therapy in the management of lower extremity ulcers due to prolidase deficiency
Author(s) -
Good Allison J.,
Nielson Colton B.,
Schoch Jennifer J.
Publication year - 2019
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13973
Subject(s) - medicine , tacrolimus , dermatology , facial dysmorphism , pediatrics , surgery , transplantation , biochemistry , chemistry , gene , phenotype
Prolidase deficiency is a rare autosomal recessive disorder characterized by cutaneous ulcers, facial dysmorphism, recurrent infections, and intellectual disability. We report a unique case of a 6‐year‐old boy with prolidase deficiency and Crohn's disease who presented with lower extremity ulcers. Cutaneous ulcers due to prolidase deficiency are historically resistant to treatment, and we report success with the novel use of topical tacrolimus.