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Successful use of topical minoxidil in the treatment of hypotrichosis associated with desmoplakin mutations
Author(s) -
Dowd Margaret,
Antonov Nina,
Garzon Maria,
Lauren Christine
Publication year - 2019
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13966
Subject(s) - medicine , dermatology , desmoplakin , hypotrichosis , minoxidil , genetics , cell , biology , gene
Syndromes associated with desmosomal protein mutations such as desmoplakin can result in hair abnormalities including congenital alopecia and hypotrichosis. Herein, we present an 8‐year‐old boy, with a combination of two heterozygous mutations in the DSP gene encoding desmoplakin associated with congenital alopecia and long‐standing hypotrichosis, who was treated with off‐label use of topical minoxidil 5% foam once daily with dramatic growth after 2 months of therapy and sustained results at 1 year. Topical minoxidil may be effective in management of congenital alopecia and hypotrichosis associated with desmoplakin mutations.