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Neonatal vesiculopustular eruption in Down syndrome and transient myeloproliferative disorder: A case report and review of the literature
Author(s) -
Brazzelli Valeria,
Segal Aviad,
Bernacca Carlotta,
Tchich Adi,
Bolcato Vittorio,
Croci Giorgio,
Mina Tommaso,
Zecca Marco,
Zanette Simona,
Stronati Mauro
Publication year - 2019
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13931
Subject(s) - medicine , trisomy , down syndrome , myeloproliferative disorders , aneuploidy , pathology , myeloid , peripheral blood , dermatology , pediatrics , immunology , chromosome , genetics , biology , psychiatry , gene
Transient myeloproliferative disorder (TMD) is a spontaneously resolving clonal myeloid proliferation characterized by circulating megakaryoblasts in the peripheral blood that is restricted to neonates with Down syndrome (DS) or those with trisomy 21 mosaicism. Cutaneous manifestations of TMD are observed in only 5% of affected neonates and present as a diffuse eruption of erythematous, crusted papules, papulovesicles, and pustules, often with prominent and initial facial involvement. We describe the case of a male infant with DS and TMD, associated with a vesiculopustular eruption, which appeared on day 36 of life, and review previous cases.