Premium
Patterned cutaneous hypopigmentation phenotype characterization: A retrospective study in 106 children
Author(s) -
Belzile Eugénie,
McCuaig Catherine,
Le Meur JeanBaptiste,
Coulombe Jérôme,
Hatami Afshin,
Powell Julie,
Rivière JeanBaptiste,
Marcoux Danielle
Publication year - 2019
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13913
Subject(s) - hypopigmentation , medicine , trunk , dermatology , phototype , biology , ecology
Background Cutaneous patterned hypopigmentation's phenotype is highly variable and may be associated with extracutaneous anomalies. Objective We evaluated the phenotypic and clinical characteristics of patients with cutaneous patterned hypopigmentation to determine whether certain patterns were more likely to be associated with underlying anomalies. Methods The charts of 106 children with cutaneous patterned hypopigmentation were reviewed retrospectively (2007‐2018) at Sainte‐Justine University Hospital Centre, in Montreal, Canada . Retrieved information included sex, age at diagnosis, phototype, pattern, and distribution of the cutaneous lesions and the presence of extracutaneous findings. Data were recorded on a software tool which collects and analyzes phenotypic information. Results The predominant types of cutaneous patterned hypopigmentation were along Blaschko's lines in narrow (38.7%) and broad bands (53.8%). Mixed patterns were observed in 22.5% of children. The anterior trunk and posterior trunk were most frequently affected (69% and 56%, respectively). Extracutaneous involvement, especially neurological and developmental, was present in 28.3% of patients and was significantly associated with ≥ 4 involved body sites. Conclusion Distribution and types of cutaneous patterned hypopigmentation were not predictive of extracutaneous findings, with the exception of multiple sites involvement and possibly centrofacial location and blocklike lesions. Follow‐up until school entry should help identify subtler associated extracutaneous anomalies.