Disseminated Bacille Calmette‐Guérin infection in a patient with severe combined immunodeficiency caused by  JAK3  gene mutation | Zendy

Li Meiyun | Zendy; Chen Zhuo | Zendy; Zhu Yunlu | Zendy; Chen Ji | Zendy

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Disseminated Bacille Calmette‐Guérin infection in a patient with severe combined immunodeficiency caused by JAK3 gene mutation

Author(s) -

Li Meiyun,

Chen Zhuo,

Zhu Yunlu,

Chen Ji

Publication year - 2019

Publication title -

pediatric dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.542

H-Index - 73

eISSN - 1525-1470

pISSN - 0736-8046

DOI - 10.1111/pde.13884

Subject(s) - medicine , severe combined immunodeficiency , immunodeficiency , vaccination , mycobacterium bovis , immunology , tuberculosis , primary immunodeficiency , attenuated vaccine , mycobacterium tuberculosis , bcg vaccine , immunity , virology , immune system , gene , pathology , biology , virulence , biochemistry

Bacille Calmette‐Guérin (BCG), a live attenuated vaccine prepared using Mycobacterium bovis , can prevent tuberculosis in children and is routinely administered to infants in China and many other countries. A serious complication following vaccination is disseminated BCG infection. The risk is greatly increased in patients with severe combined immunodeficiency disease (SCID), a syndrome characterized by deficiency of both humoral and cellular immunity. We report a case of disseminated BCG infection in an infant with SCID caused by two novel janus kinase 3 ( JAK3 ) gene mutations.

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