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Panniculitis in a 3‐year‐old child with Fanconi anemia‐associated bone marrow hypoplasia heralds transformation to acute myeloid leukemia
Author(s) -
Webber Lucy,
Cummins Michelle,
Mann Rebecca,
Shaw Lindsay,
Ghinai Rosanna,
Mahon Caroline
Publication year - 2019
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13872
Subject(s) - medicine , fanconi anemia , bone marrow failure , myeloid leukemia , acute leukemia , malignancy , hypoplasia , leukemia , malignant transformation , pathology , dermatology , immunology , haematopoiesis , stem cell , genetics , dna repair , gene , biology
Fanconi anemia is a rare, autosomal recessive genomic instability disorder characterized by congenital limb anomalies, panmyelopathy and a high risk of malignancy, principally acute myeloid leukemia. Hematologic malignancy presenting with acute febrile neutrophilic dermatosis (Sweet syndrome), both deep and superficial forms, is well described in Fanconi anemia patients but is a rare phenomenon in otherwise healthy children. We present a case of panniculitis (presumptive subcutaneous Sweet syndrome) heralding transformation to acute myeloid leukemia in a 3‐year‐old boy with a severe Fanconi anemia phenotype.