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Severe vemurafenib‐induced photosensitivity in a 6‐year‐old boy
Author(s) -
Jew Olivia S.,
Provini Lauren E.,
Treat James R.
Publication year - 2018
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13720
Subject(s) - vemurafenib , medicine , dermatology , sunburn , photosensitivity , adverse effect , basal cell , keratosis , cancer research , melanoma , metastatic melanoma , physics , quantum mechanics
Vemurafenib, a selective BRAF kinase inhibitor, has been found to induce several cutaneous adverse effects, ranging from a keratosis pilaris‐like reaction to squamous cell carcinoma. While photosensitivity has been well described as one of these manifestations, we report a case of a 6‐year‐old boy on vemurafenib who developed a severe blistering sunburn after only two 30‐minute episodes of sun exposure. A brief review of other common cutaneous adverse effects of vemurafenib is also provided.