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Congenital tufted angioma: A multicenter retrospective study of 30 cases
Author(s) -
FeitoRodríguez Marta,
SánchezOrta Alba,
De Lucas Raúl,
LópezGutiérrez Juan Carlos,
RuizBravo Elena,
Baselga Eulalia,
Victoria Ana M.,
HernándezMartín Angela,
CamposDomínguez Minia,
Berenguer Fröhner Beatriz,
GarnachoSaucedo Gloria,
Vera Casaño Angel,
Vicente Villa Asunción,
BernabeuWittel José,
Kutzner Heinz,
Requena Luis
Publication year - 2018
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13683
Subject(s) - medicine , retrospective cohort study , histopathology , angioma , hemangioma , pathology , surgery , vascular disease
Background Recent reports indicate that tufted angioma is a rare vascular neoplasm that manifests more frequently at birth than previously thought. Few studies specifically address congenital presentation. Objectives We analyzed the clinicopathological characteristics, clinical course, and treatment of congenital tufted angioma ( cTA ) and evaluated variables that were indicative of problematic lesions. Methods We performed an observational retrospective study of 30 patients with cTA in 9 Spanish hospitals over a 14‐year period. Histopathology and immunohistochemistry studies were performed. Results Congenital tufted angioma mainly affected the limbs (56.67%), followed by the face and/or neck (23.33%). Almost three‐quarters of facial cTA were located over the mandibular area. Immunohistochemically, proliferating cells expressed markers of endothelial cells, with some clusters of cells, especially at the periphery of the aggregates, showing positivity for podoplanin. As no associated complications were observed in 66.67% of cases, no treatment was started. Limitations Data were collected retrospectively. Conclusions Our findings emphasize the clinical features and course of cTA . The possibility of cTA should be considered when a poorly defined congenital infiltrative vascular tumor with(out) overlying hirsutism appears over the mandibular area. Location on the face and/or neck requires a more comprehensive workup, since potentially severe complications often appear early.