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Granulomatous dermatitis secondary to vemurafenib in a child with Langerhans cell histiocytosis
Author(s) -
Chen Lily,
Hsi Andy C.,
Kothari Alok,
Dehner Louis P.,
Hayashi Robert J.,
Coughlin Carrie C.
Publication year - 2018
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13613
Subject(s) - vemurafenib , langerhans cell histiocytosis , medicine , dermatology , melanoma , histiocytosis , pathology , metastatic melanoma , cancer research , disease
We present a 3‐year‐old boy with Langerhans cell histiocytosis who developed granulomatous dermatitis while taking vemurafenib. Vemurafenib currently has Food and Drug Administration approval for the treatment of BRAF V600E+ metastatic melanoma in adults, but recent discoveries of BRAF V600E in more than half of tested Langerhans cell histiocytosis lesions have prompted clinical trials of vemurafenib therapy for children with refractory, multisystem Langerhans cell histiocytosis. This report contributes to the knowledge of its potential side effects when used in children.