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Aggressive melanoma in an infant with congenital melanocytic nevus syndrome and multiple, NRAS and BRAF mutation‐negative nodules
Author(s) -
Rosa Carrillo Daniel,
Vindenes Harald,
Kinsler Veronica A.,
Rønnestad Arild,
Ringstad Geir,
Müller LilSofie Ording,
Tafjord Svetlana,
Tønseth Kim A.,
Kvamme Bjørn,
Clausen Ole Petter Fraas
Publication year - 2018
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13595
Subject(s) - medicine , neuroblastoma ras viral oncogene homolog , congenital melanocytic nevus , nevus , melanoma , melanocytic nevus , pathology , atypia , histopathology , dermatology , cancer , cancer research , colorectal cancer , kras
We report the case of a newborn boy with multinodular NRAS and BRAF mutation‐negative congenital melanocytic nevi and cerebral lesions compatible with congenital intraparenchymal melanosis. Histopathology from skin lesions showed atypical nodular melanocytic proliferation with marked melanocytic atypia and a large number of mitoses and apoptosis, indicating aggressive proliferation. The child developed several new subcutaneous tumors and multiple internal lesions, which were confirmed to be metastases, and died at 5 months of age. This case may represent an infantile melanoma developing from a giant congenital melanocytic nevus or a congenital melanoma.