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Omeprazole‐induced hypertrichosis in two children
Author(s) -
ElosuaGonzález Marta,
CamposDomínguez Minia,
Bancalari Daniel,
NogueraMorel Lucero,
HernándezMartín Angela,
HuertaAragonés Jorge,
Torrelo Antonio
Publication year - 2018
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13496
Subject(s) - omeprazole , hypertrichosis , prostaglandin , medicine , prostaglandin e2 , endocrinology , prostaglandin e , pharmacology
Omeprazole significantly increases duodenal prostaglandin E 2 synthesis. Prostaglandins are involved in hair growth regulation: prostaglandin E 2 and prostaglandin F 2 alpha stimulate hair growth, and prostaglandin D 2 has an inhibitory effect. The use of omeprazole can cause acquired generalized hypertrichosis by increasing prostaglandin E 2 levels.
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