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Pyoderma gangrenosum in an infant: A case report and review of the literature
Author(s) -
Crouse Lauren,
McShane Diana,
Morrell Dean S.,
Wu Eveline Y.
Publication year - 2018
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13471
Subject(s) - pyoderma gangrenosum , tacrolimus , medicine , dapsone , dermatology , neutrophilic dermatosis , infliximab , surgery , transplantation , tumor necrosis factor alpha , disease
Pyoderma gangrenosum is a neutrophilic dermatosis that is rare in infancy, with only 20 cases reported in the literature. We present a case of infantile pyoderma gangrenosum refractory to topical steroids, tacrolimus, and dapsone as well as systemic steroids and infliximab that is currently well controlled with the addition of oral tacrolimus. To our knowledge, this is the first report of the effective, safe use of oral tacrolimus in combination with infliximab for infantile pyoderma gangrenosum. We review all current cases of infantile pyoderma gangrenosum, as well as tacrolimus and its role in the treatment of this condition.