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Perinuclear antineutrophil cytoplasmic antibody–positive vasculitis, oligoarthritis, tendinitis, and myositis associated with isotretinoin in a 15‐year‐old boy: Case report and review of literature
Author(s) -
Mangodt Thomas C.,
Joos Rik,
Siozopoulou Vasiliki,
Cortoos PieterJan,
Baeten Hans,
Docx Martine,
Akker Machiel
Publication year - 2018
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13445
Subject(s) - medicine , oligoarthritis , anti neutrophil cytoplasmic antibody , dermatology , myositis , vasculitis , myalgia , isotretinoin , discontinuation , autoantibody , immunology , polyarthritis , antibody , pathology , arthritis , disease , acne
We present a patient in whom a combination of perinuclear antineutrophil cytoplasmic antibody–positive vasculitis, oligoarthritis, tendinitis, and myositis was considered to be associated with isotretinoin use. Discontinuation of the drug resulted in complete clinical and biochemical remission (normalization of perinuclear antineutrophil cytoplasmic antibody titer). Although we were unable to prove causality, no other underlying cause for the patient's course was found. We report this occurrence to bring it to the attention of physicians prescribing isotretinoin.