Premium
Mood changes with methotrexate therapy for dermatologic disease
Author(s) -
Bhat Trisha,
Coughlin Carrie C.
Publication year - 2018
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13406
Subject(s) - methotrexate , medicine , lichen sclerosus , psoriasis , morphea , dermatology , mood , disease , antifolate , radiation therapy , antimetabolite , psychiatry
Abstract Neurotoxicity and cognitive effects of low‐dose methotrexate for rheumatologic disease have often been described, but the neuropsychiatric effects of low‐dose methotrexate for cutaneous disease have been underreported in the dermatology literature. We describe two children who experienced mood changes with methotrexate treatment for lichen sclerosus with morphea overlap and psoriasis, with rapid resolution of these symptoms after methotrexate cessation. We also detail possible mechanisms underlying psychiatric changes with methotrexate therapy.