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Circadian rhythm in atopic dermatitis—Pathophysiology and implications for chronotherapy
Author(s) -
Vaughn Alexandra R.,
Clark Ashley K.,
Sivamani Raja K.,
Shi Vivian Y.
Publication year - 2017
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13364
Subject(s) - circadian rhythm , chronotherapy (sleep phase) , atopic dermatitis , medicine , transepidermal water loss , rhythm , chronobiology , dermatology , pathology , stratum corneum
Circadian rhythm is a biological clock that controls a wide range of physiological functions throughout the body, including various skin functions. A 24‐h diurnal cycle, governed by an endogenous clock in the brain, largely controls cutaneous diurnal rhythm, which external factors, including temperature, humidity, diet, and stress, also modulate locally. Circadian rhythm influences cutaneous blood flow and properties of skin barrier function, such as transepidermal water loss and capacitance, and has important implications in atopic dermatitis (AD). This review explores how aberrations in circadian rhythm may play a role in the pathogenesis of AD and proposes implementation of chronotherapy to improve treatment outcomes in patients with AD.