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Aplasia cutis congenita: Evaluation of signs suggesting extracutaneous involvement
Author(s) -
Patel Deepa P.,
CasteloSoccio Leslie,
Yan Albert C.
Publication year - 2017
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13340
Subject(s) - aplasia cutis congenita , medicine , aplasia , skull , lesion , scalp , pathology , dermatology , anatomy
Specific clinical features of aplasia cutis congenita may indicate the presence of underlying cranial or cerebrovascular defects, allowing for early recognition and intervention. Most information about aplasia cutis congenita exists as individual case reports, with few large‐scale studies. We conducted a 7‐year retrospective chart review of 90 cases of aplasia cutis congenita and identified clinical characteristics including morphology, number of lesions, anatomic location, presence of hair collar sign, associated cutaneous features, histology, and imaging results. The anatomic location of the lesion (vertex, midline) ( P = .01), presence of hair collar sign ( P < .001), vascular stains ( P < .001), and nodules ( P = .007) were found to be strong clinical indicators of skull or cerebrovascular involvement.