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Keratoacanthoma‐Like Growths of Incontinentia Pigmenti Successfully Treated with Intralesional Methotrexate
Author(s) -
Barros Brittany,
Helm Klaus,
Zaenglein Andrea,
Seiverling Elizabeth
Publication year - 2017
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13142
Subject(s) - keratoacanthoma , medicine , incontinentia pigmenti , dermatology , nodule (geology) , methotrexate , biopsy , pathology , surgery , basal cell , biology , paleontology
We report the case of a 17‐year‐old girl with incontinentia pigmenti who developed multiple large hyperkeratotic tumors within Blaschkoid hyperpigmented patches on her left leg. Biopsy demonstrated an endoexophytic nodule with irregular invaginations of keratinizing squamous epithelium and a central keratin‐filled crater, consistent with keratoacanthoma‐like lesions of incontinentia pigmenti. The tumors were successfully treated with intralesional methotrexate.