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Neonatal Endocrinologic Problems in Collodion Babies
Author(s) -
Ozdemir Ahmet,
Korkut Sabriye,
Kurtoglu Selim,
Hatipoglu Nihal,
Gunes Tamer,
Ozturk Mehmet Adnan
Publication year - 2017
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13120
Subject(s) - medicine , endocrinology , gestational age , subclinical infection , small for gestational age , birth weight , pregnancy , biology , genetics
Abstract Objectives To identify endocrinologic problems, particularly those concerning growth, in collodion babies ( CB s). Methods Clinically identified newborn CB s were included in the study group (group 1). Because CB s are generally born premature, small for gestational age ( SGA ), or both, a control group matched to the study group in terms of gestational age and birthweight (group 2) was also established. Blood specimens were collected from both groups for thyroid function tests and to measure serum growth hormone ( GH ), insulinlike growth factor 1 ( IGF ‐1) and IGF binding protein‐3 ( IGFBP ‐3) levels. Results Group 1 consisted of 42 CB s (25 male, 17 female) with gestational ages of 32 to 42 weeks and birthweights of 1,400 to 4,000 g. Twelve were assessed as premature and 17 as SGA . Serum IGF ‐1 and IGFBP ‐3 levels were lower and serum GH levels higher than in controls. Primary hypothyroidism was diagnosed in 10 patients in the study group, subclinical hypothyroidism in 2, and central hypothyroidism in 1. A statistically significant difference was determined between the groups in terms of primary hypothyroidism (p = 0.01). Serum GH levels were weakly negatively correlated with birthweight (correlation coefficient [ r ] = −0.32, p = 0.04) and serum IGF ‐1 ( r = −0.38, p = 0.001) and IGFBP ‐3 ( r = −0.36, p = 0.002) levels. Conclusion Premature birth and SGA are common in CB s. GH levels are high and IGF ‐1 and IGFBP ‐3 levels low at birth as a sign of GH resistance in these patients. The greater prevalence of hypothyroidism in these children is also significant.