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Intragenic Copy Number Variation in the Filaggrin Gene in Ethiopian Patients with Atopic Dermatitis
Author(s) -
Fernandez Kerstin,
Asad Samina,
Taylan Fulya,
Wahlgren CarlFredrik,
Bilcha Kassahun D.,
Nordenskjöld Magnus,
Winge Mårten C.G.,
Bradley Maria
Publication year - 2017
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13095
Subject(s) - filaggrin , atopic dermatitis , copy number variation , medicine , genetic variation , genetics , gene , dermatology , biology , genome
Genetic variants in filaggrin ( FLG ) involving truncating mutations or intragenic copy number variation are strongly associated with the risk of developing atopic dermatitis (AD) in European and Asian populations. Few loss‐of‐function mutations have been identified in Africans, although an association between FLG copy number variation and AD severity in a small African American cohort has been proposed. We studied the association between FLG copy number and AD in 132 Ethiopians and found no association between AD severity and FLG copy number, suggesting that other, still unidentified genetic factors are of more importance in predisposing Ethiopians to AD .