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Immunohistochemical Staining of Pediatric Solitary Angiokeratomas
Author(s) -
Prindaville Brea,
Lawrence Hillary,
Singh Vivekanand,
Nopper Amy J.,
Horii Kimberly A.
Publication year - 2017
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13089
Subject(s) - medicine , pathology , lymphatic system , immunohistochemistry
The precise etiology and subtype of vessels constituting angiokeratomas is poorly understood. We sought to characterize the vessels by studying prospero‐related homeobox gene‐1 and D2‐40 expression in 22 pediatric solitary angiokeratomas. Routine histologic examination demonstrated a mix of lymph‐containing vessels and erythrocyte‐filled small vessels. Our results suggest that angiokeratomas may in part be comprised of vessels with lymphatic differentiation.