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Pemphigus Vulgaris and Eosinophilic Esophagitis in a 13‐Year‐Old Boy: Case Report and Review of the Literature
Author(s) -
Gue Sumant,
Huang Gwendolyn,
Moore Lynette,
Hammond Paul,
Boros Christina A.
Publication year - 2017
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13086
Subject(s) - medicine , eosinophilic esophagitis , pemphigus vulgaris , dermatology , eosinophilic , biopsy , esophagitis , pathology , disease , reflux
This case report presents a 13‐year‐old boy referred to the Department of Paediatric Dentistry, Women's and Children's Hospital, Adelaide, South Australia, Australia, with a 5‐week history of severe oral ulcerations and significant weight loss of unknown origin. The diagnosis of pemphigus vulgaris was made after histologic and immunofluorescent examination of an intraoral deep incisional biopsy, with eosinophilic esophagitis also diagnosed during the initial upper gastrointestinal endoscopy. The association between pemphigus vulgaris and eosinophilic esophagitis in this case, although previously unreported, is explicable on the basis of dysregulation of desmoglein 1 (DSG1). This case report identifies a new clinical association that could help clinicians identify further such cases and provides insight into the pathogenesis of both conditions.