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Atopic Dermatitis in Israeli Adolescents from 1998 to 2013: Trends in Time and Association with Migraine
Author(s) -
ShreberkHassidim Rony,
Hassidim Ayal,
Gronovich Yoav,
Dalal Adam,
MolhoPessach Vered,
Zlotogorski Abraham
Publication year - 2017
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13084
Subject(s) - medicine , atopic dermatitis , odds ratio , asthma , confidence interval , population , cross sectional study , socioeconomic status , migraine , epidemiology , pediatrics , demography , environmental health , dermatology , pathology , sociology
Background Recent data have shown an increasing occurrence of atopic dermatitis ( AD ) in children and adolescents, as well as in adults. Most of the epidemiologic research on AD is limited to pediatric and youth populations and is based on self‐reported questionnaires. Methods A nationwide, population‐based, cross‐sectional retrospective study of adolescents with AD was performed to estimate its prevalence, trends, and association with demographic factors and comorbidities. The study included all Israeli teens going through medical evaluation as part of the assessment before being conscripted into the military from 1998 to 2013. Results A total of 1,187,757 adolescents were included in the study population, with an overall prevalence of AD of 0.64% in boys and 0.9% in girls. Over the study period, the prevalence of AD steadily increased, especially in the mild disease group. A greater risk of AD was found in subjects with high predicted socioeconomic status (male: odds ratio [ OR ] 1.14 [95% confidence interval { CI } 1.11, 1.16]; female: OR 1.08, [95% CI 1.05, 1.10]) and Israeli‐born subjects (male: OR 1.34 [95% CI 1.21, 1.48]; female: OR 1.12 [95% CI 1.01, 1.23]). Allergic conditions such as asthma, conjunctivitis, and contact dermatitis were more prevalent in subjects with AD . There was a significantly higher prevalence of migraine in patients with AD (male: OR 1.35 [95% CI 1.18, 1.54]; female: OR 1.51 [95% CI 1.30, 1.74]). Conclusion This large cross‐sectional study demonstrates the increasing prevalence of AD in adolescents and its relation to other allergic diseases and migraine. It is hoped that greater awareness of the distinctive epidemiologic characteristics of this population will lead to better recognition and management of the disease and its comorbidities.