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Drug Hypersensitivity Syndrome with Prolonged Course Complicated by Parvovirus Infection
Author(s) -
Coughlin Carrie C.,
Jen Melinda V.,
Boos Markus D.
Publication year - 2016
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.13007
Subject(s) - medicine , parvovirus , drug , immunology , dermatology , virology , pharmacology , virus
Drug hypersensitivity syndrome ( DHS ) is a severe medication reaction involving multiple organ systems that is characterized by rash, lymphadenopathy, and laboratory aberrations, including hepatic enzyme changes. Viral reactivation in the setting of DHS can significantly affect the course of disease. We report two children in whom parvovirus infection prolonged and complicated their course of DHS . Most other DHS ‐complicating viruses are herpesviruses; this report broadens the scope of DHS ‐modifying infections to include activation of Parvoviridae .