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Sudden Onset of Papular Elastorrhexis After Immunologic Recovery in a Boy with Human Immunodeficiency Virus
Author(s) -
RodríguezLomba Enrique,
MolinaLópez Irene,
ParraBlanco Verónica,
SuárezFernández Ricardo,
CamposDomínguez Minia
Publication year - 2016
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.12979
Subject(s) - medicine , etiology , asymptomatic , virus , immune system , immune dysregulation , immunodeficiency , disease , immunology , pathological , elastin , human immunodeficiency virus (hiv) , immunopathology , pathology
Abstract Papular elastorrhexis ( PE ) is an uncommon elastic tissue disorder clinically characterized by the onset of asymptomatic flesh‐colored to whitish papules over the trunk and upper limbs in children. Its etiology remains unknown, although isolated familial cases have suggested that acquired and inherited forms of the disease may exist. We present the case of a 13‐year‐old boy with human immunodeficiency virus who presented with such lesions after immunological recovery from very low CD 4 + counts after introducing highly active antiretroviral therapy. Because neutrophils and macrophages are implicated in elastin metabolism and degradation pathways, immune dysregulation might be another etiologic factor to be considered in this rare disease.