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Myelodysplastic Syndrome Occurring in a Patient with Gorlin Syndrome
Author(s) -
Mull Jamie L.,
Madden Lisa M.,
Bayliss Susan J.
Publication year - 2016
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.12880
Subject(s) - medicine , complication , medulloblastoma , myelodysplastic syndromes , chemotherapy , radiation therapy , bone marrow , pediatrics , surgery , pathology
We report a case of myelodysplastic syndrome ( MDS ) occurring in an African American boy with Gorlin syndrome with a novel PTCH 1 mutation. Before developing MDS , the patient had been treated with chemotherapy and radiation for a medulloblastoma. He received a bone marrow transplant for the MDS and eventually died of treatment complications. Secondary hematologic malignancies are a known complication of certain chemotherapeutics, although whether a patient with Gorlin syndrome has a greater propensity for the development of such malignancies is unclear.