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Atypical Fibroxanthoma in a 13‐Year‐Old Guatemalan Girl with Xeroderma Pigmentosum
Author(s) -
Chappell Ava G.,
Chase Elizabeth P.,
Chang Beverly,
Cunningham Eric,
Mihm Fred,
Calame Antoanella,
Fudem Gary,
Cunningham Bari
Publication year - 2016
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.12852
Subject(s) - xeroderma pigmentosum , atypical fibroxanthoma , medicine , dermatology , girl , photodermatosis , pathology , genetics , dna repair , dna , biology , immunohistochemistry
Xeroderma pigmentosum ( XP ) is a rare, autosomal recessive disease involving a defect in DNA repair leading to the premature development of numerous aggressive cutaneous malignancies. Although atypical fibroxanthoma ( AFX ) is a neoplasm typically found in the setting of extensive sun exposure or therapeutic radiation, AFX s are rarely associated with children with XP . We report the case of a 13‐year‐old Guatemalan girl with the XP type C variant who developed one of the largest AFX s reported on a child's finger.