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Association Between Discoid Lupus Erythematosus and Chronic Granulomatous Disease—Report of Two Cases and Review of the Literature
Author(s) -
Xie Charles,
Cole Theresa,
McLean Catriona,
Su John C.
Publication year - 2016
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.12826
Subject(s) - chronic granulomatous disease , medicine , pathogenesis , immunology , discoid lupus erythematosus , dermatology , systemic lupus erythematosus , lupus erythematosus , population , disease , pathology , antibody , environmental health
Discoid lupus erythematosus (DLE) is known to be associated with chronic granulomatous disease ( CGD ), but most DLE occurs in female carriers of X‐linked CGD , with few reports of these lesions in CGD ‐affected individuals—this observation is unexplained. We describe two cases of DLE ‐like lesions in boys with CGD : one boy with partial neutrophil function and another whose lesions were related to voriconazole use. Reviewing other previously reported cases, we conclude that the risk of developing DLE ‐like lesions appears to be greater primarily in two subsets of the population with CGD : those with partial neutrophil function and those with near‐absent neutrophil function in whom there is a second trigger. In light of recent literature on the role of neutrophils in lupus pathogenesis, we propose that pathogenesis of DLE in CGD may be related to NET osis, neutrophil dysfunction and a deficiency of reactive oxygen species, which medications such as voriconazole also influence.