Premium
High‐Potency Topical Steroids: An Effective Therapy for Chronic Scalp Inflammation in Rapp–Hodgkin Ectodermal Dysplasia
Author(s) -
Theiler Martin,
Frieden Ilona J.
Publication year - 2016
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.12784
Subject(s) - scalp , medicine , dermatology , ectodermal dysplasia , refractory (planetary science) , inflammation , scarring alopecia , physics , astrobiology
Chronic erosive pustular dermatitis with a predilection for the scalp is a hallmark of ectodermal dysplasias ( ED s) caused by mutations in TP 63 , including R app– H odgkin and H ay– W ells ED s. It is among the most troublesome and symptomatic complications and is typically refractory to classic wound care approaches. We report two cases of R app– H odgkin ED with refractory scalp erosions that markedly improved with the use of potent topical steroids. We also note marked similarities between this scalp inflammation and “erosive pustular dermatosis of the scalp,” a condition more typically found in elderly individuals with severe scalp sun damage, and speculate about possible shared pathogenetic mechanisms.