Premium
Excipients in Oral Antihistamines Can Perpetuate Allergic Contact Dermatitis
Author(s) -
Tocci Elizabeth M.,
Robinson Amanda,
Belazarian Leah,
Foley Elizabeth,
Wiss Karen,
Silvestri Dianne L.
Publication year - 2015
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.12668
Subject(s) - medicine , allergen , contact dermatitis , allergic contact dermatitis , dermatology , polyvinyl alcohol , allergy , atopic dermatitis , anaphylaxis , patch testing , immunology , chemical engineering , engineering
Abstract Propylene glycol is a well‐documented causative agent of allergic contact dermatitis ( ACD ). It is also reported to cause systemic dermatitis after ingestion of foods or medicines containing it and after intravenous injection of a medicine with propylene glycol in its base. We describe two adolescents with sensitivity to propylene glycol confirmed by patch testing whose dermatitis improved dramatically after cessation of oral antihistamines containing propylene glycol. We report these cases to alert providers to the potential for worsening of ACD due to systemic exposure to propylene glycol in patients with a cutaneous sensitivity to the allergen.