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Combination Systemic Fluorouracil and Radiation for the Treatment of Recalcitrant Condyloma with Associated Squamous Cell Carcinoma in an Immunocompromised 15‐Year‐Old Girl
Author(s) -
Paul Suchismita,
Cheng Carol E.,
Kroshinsky Daniela
Publication year - 2015
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.12617
Subject(s) - medicine , fluorouracil , dermatology , genital warts , mitomycin c , radiation therapy , girl , carcinoma , basal cell , oncology , cancer , pathology , surgery , cervical cancer , psychology , developmental psychology
Condylomata acuminata ( CA ), or anogenital warts, are typically benign lesions caused by human papillomavirus infection. Although they are rare, immunocompromised individuals are at a higher risk of CA undergoing transformation into invasive anal squamous cell carcinoma ( SCC ). These patients need aggressive evaluation and management. Treatment of CA is challenging, particularly for immunocompromised hosts, in whom warts are resistant to treatment and commonly recur. Currently, there is no gold standard treatment for CA , especially in children and immunodeficient individuals. We report the case of a 15‐year‐old immunocompromised girl with severe recalcitrant condyloma that resolved after a course of systemic 5‐fluorouracil, mitomycin C, and radiation therapy for SCC .