Oral Cyclosporine Weekend Therapy: A New Maintenance Therapeutic Option in Patients with Severe Atopic Dermatitis | Zendy

Garrido Colmenero Cristina | Zendy; Blasco Morente Gonzalo | Zendy; Tercedor Sánchez Jesús | Zendy

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Oral Cyclosporine Weekend Therapy: A New Maintenance Therapeutic Option in Patients with Severe Atopic Dermatitis

Author(s) -

Garrido Colmenero Cristina,

Blasco Morente Gonzalo,

Tercedor Sánchez Jesús

Publication year - 2015

Publication title -

pediatric dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.542

H-Index - 73

eISSN - 1525-1470

pISSN - 0736-8046

DOI - 10.1111/pde.12592

Subject(s) - medicine , atopic dermatitis , scorad , cumulative dose , ciclosporin , severity of illness , dermatology , chemotherapy , disease , dermatology life quality index

Cyclosporine A (CyA) is a systemic therapy used to control severe atopic dermatitis ( AD ) in children, but its use may be associated with serious side effects. Intermittent short‐course therapy has been used to minimize these risks without the loss of clinical benefits. We conducted a 20‐week study using intermittent short‐course CyA therapy in five patients with severe AD and a Scoring Atopic Dermatitis ( SCORAD ) score >40. The result was a reduction in the cumulative dose of CyA and serum CyA level, which allows for a longer duration of CyA treatment and decreases the risk of relapse in patients with severe AD .

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