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Suplatast Tosilate for Treating Cutaneous Mastocytosis
Author(s) -
Yasudo Hiroki,
Ando Tomoaki,
Hiwatari Mitsuteru,
Oka Akira
Publication year - 2015
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.12552
Subject(s) - medicine , cutaneous mastocytosis , antihistamine , dermatology , allergy , fluticasone propionate , mast cell , systemic mastocytosis , asthma , immunology
Pediatric cutaneous mastocytosis is a rare disease caused by mast cell hyperplasia. We report the case of an infant diagnosed as cutaneous mastocytosis and seasonal allergies. The wheals, flushing, and pruritus of the mastocytosis were unresponsive to combination therapy with an antihistamine, a mast cell stabilizer (sodium cromoglycate), and a leukotriene antagonist. Addition of suplatast tosilate as a treatment for the seasonal allergy also dramatically improved his cutaneous symptoms and signs. Further trials of suplatast tosilate in selected cases of cutaneous mastocytosis are warranted.