Premium
Purpuric Eruption in a Transfused Neonate Receiving Phototherapy
Author(s) -
By Charya C.,
Owens Alexandra,
Wesson Stanton K.
Publication year - 2014
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.12438
Subject(s) - medicine , hemolysis , photosensitivity , anemia , pathogenesis , reticulocyte , urine , immunology , unconjugated hyperbilirubinemia , physiology , gastroenterology , jaundice , biochemistry , chemistry , physics , quantum mechanics , messenger rna , gene
We describe the clinical and biochemical findings in a neonate requiring multiple blood transfusions and phototherapy for alloimmune hemolytic anemia and unconjugated hyperbilirubinemia, respectively. In this newborn, a severe photosensitivity reaction developed and laboratory testing revealed elevated serum and urine porphyrins at the time of the eruption. The cause of the transient porphyrinemia was likely multifactorial. Possible mechanisms include poor hepatic metabolism and reticulocyte hemolysis. However, the exact pathogenesis remains unclear at this time.