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Practical Application of the New Classification Scheme for Congenital Melanocytic Nevi
Author(s) -
Price Harper N.,
O'Haver Judith,
Marghoob Ashfaq,
Badger Kellie,
Etchevers Heather,
Krengel Sven
Publication year - 2014
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.12428
Subject(s) - medicine , dermatology , melanoma , asymptomatic , congenital melanocytic nevus , nevus , surgery , cancer research
A new consensus‐based classification of congenital melanocytic nevi ( CMN ) has recently been proposed. It includes categories for projected adult size ( PAS ) and location, satellite nevi counts, and morphologic characteristics (color heterogeneity, rugosity, nodularity, and hypertrichosis). The objective of the current study was to test the applicability of the new categorization scheme and to correlate classification outcome with the patient's history of melanoma and neurocutaneous melanocytosis ( NCM ). Children and adults with CMN attending a patient conference in D allas, T exas, in 2012 were invited to participate in the study. Anamnestical data were collected using a standardized questionnaire. Two dermatologists performed clinical examinations. Of 45 patients enrolled, 33 had a giant CMN ( G 1 [>40 cm PAS ], n = 13; G 2 [>60 cm PAS ], n = 20), 12 had an NCM (5 symptomatic, 7 asymptomatic), and 1 had a history of melanoma. CMN size was positively correlated with NCM (p < 0.05). The classification system allowed an easy and detailed phenotypic characterization of each individual CMN . CMN size and morphology were difficult to assess in patients after surgical removal, and the number of satellite nevi at birth or during infancy was not always known. Our report provides practical aids for the application of the newly proposed CMN classification. Prospective evaluation of accurately classified patients in CMN registries will reveal the predictive value of the scheme. The small study sample limits meaningful conclusions regarding the correlation between CMN parameters and the risk of NCM and melanoma.